Preemptive analgesia effects of flurbiprofen axetil or tramadol in patients undergoing sevoflurane general anesthesia

Objective To compare the preemptive analgesia effect of flurbiprofen axetil and tramadol in sevoflurane general anasthesia and evaluate the preventive effect of flurbiprofen axetil and tramadol on postoperative agitation.Methods Sixty ASA Ⅰ-Ⅱ patients undergoing choledochotomy were randomly assigned into three groups,which received either a bolus of 1 mg/kg flurbiprofen axetil(the flurbiprofen axetil group,20 cases) or 2 mg/kg tramadol(the tramadol group,20 cases) or 10 ml normal saline (the normal saline group,20 cases),10 min before the surgery.The heart rate (HR),mean arterial blood pressure (MAP) and pulse oxygen saturation (SpO2) before induction of anesthesia and peri-extubation,the moment of eyes opening and extubation,and the degree of postoperative agitation were recorded.Results The MAP、HR in the flurbiprofen axetil group and the tramadol group were significantly lower than that of the normal saline group peri-extubation(P＜0.05 or P＜0.01),SpO2 was not significantly different in all groups.The time of eye opening and extubation in the flurbiprofen axetil group [(11 ±4),(13±3) min] were significantly shorter than that of the tramadol group [(15±4),(18±5) min] (P＜0.05).The emergence of postoperative agitation in the flurbiprofen axetil group(0) and the tramadol group(20％) were significantly better than that of the normal saline group(55％)(P＜0.05 or P＜0.01),and the visual analogue score in the flurbiprofen axetil group[(2.2±0.6),(2.1±0.8)] and the tramadol group[(3.0±1.1),(2.6±1.0)] after the operation finished 0.5 h and 2 h were significantly better than that of the normal saline group [(4.1 ±0.7),(3.9±0.6)] (P＜0.05).Conclusions Applying of flurbiprofen axetil and tramadol in sevoflurane general anasthesia can provide a good effect of preemptive analgesia and prevent postoperative agitation.But tramadol would prolong the waking time of patients. Key words: Flurbiprofen axetil;  Tramadol;  Preemptive analgesia;  Postoperative agitation