Comparison of analgesic efficacy between flurbiprofen axetil and tramadol in patients post cranioectomy axetil;Tramadol;Postoperative analgesia in neurosurgery

Objective To compare the analgesic efficacy and adverse reactions of flurbiprofen axetil and tramadol in patients undergoing neurosurgery.Methods Sixty patients undergoing neurosurgery were randomly divided into 2 groups(n=30).Group A was administered with 1.5 mg/kg flurbiprofen axetil 30 min before the end of operation;group B was administered with 2 mg/kg tramadol 30 min before the end of operation.The visual analogue scale(VAS) pain score,sedation,nausea and vomiting score were detected at 1 h,3 h,6 h after operation,and the blood oxygen,heart rate,respiratory frequency were recorded.Results The analgesic effects of group A at different time was better than that of group B(P0.05),and the incidence of adverse reactions of group A,such as nausea and vomiting,was lower than that of group B(P0.05).Conclusion Flurbiprofen axetil has a good curative effect for postoperative analgesia in neurosurgery with a lower incidence of adverse reactions compared with tramadol.