Efficacy analysis of carvedilol in treatment of chronic heart failure

Objective To observe the clinical therapeutic effect and safety of carvedilol in the treatment of chronic heart failure. Methods Sixty -eight cases of patients with chronic CHF were randomly divided into two groups:one group was received routine treatment (digitalis, diuretics, vasodilator, ACEI), and another group was received carvedilor (25 nag, bid × 90 d)as well as routine treatment. Results The treatment, efficiency in carvedilol group and control group were respectively 91.3% and 65.2% with significent difference between two groups, P <0. 01). No adverse reactions associated with carvedilol were observed. The improvements of HR, BP, LVEF, EDV, ESV after treatment in carvedilol group were significant (P < 0. 01 orP < 0. 05). Conclusions Adding carvedilol based on the routine therapy can improve the effect and the heart function. Carvedilol is a safe and effective drug. Key words: Carvedilol; Chronic congestive heart failure;  β adrenoceptor bloker