Analysis and clinic meaning of chromosome karyotypes of 2756 genetic counseling

Objective To analysis the relationship between abnormal karyotypes and chromosome and diseases,to offer basics for clinic genetic counseling.Methods 2 756 peripheral blood samples from outpatients with genetic counseling were tested for chromose karyotype.Results There were 181 cases of abnormal karyotypes with the rate of abnormal karyotypes of 6.57%,0f which,43 cases were Down's syndrome(1.56%),74 cases were abnormal karyotypes of euchromosome(2.69%),64 cases were abnormal karyotypes of sex chromosome(2.32%).Conclusions The abnormal karyotype is the most common reason causing natural abortion,fetal death,congenital malformation,feeblemindedness,dead fetus,primary amenorrhea,infertility for man and obstacle of growth development.Chromose karyotype should be tested for these patients.