2010•Int J Cerebrovasc DisRequires access

Fractalkine and its receptor CX3 CRI and cerebrovascular diseases

Lie Wu

Abstract

Fractalkine is a new member of chemokine family, which exists in membranebound form and soluble form. It has both adhesion molecular and chemokine activities. CX3 CR1 is its specific receptor. Both of them were expressed in many diseases of the nervous system. At present, fractalkine and its receptor CX3 CR1 polymorphism and the research of cerebrovascular diseases mainly involve in the risk factors for cerebrovascular diseases, cerebral ischemiareperfusion and bone marrow stem cell transplantion, which are expected to become a new target for clinical treatment. Key words: Cerebrovascular disorders; Brain ischemia; Reperfusion injury; Chemokines, CX3C; Receptors, cytokine; Polymorphism, genetic

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Key concepts: CX3CL1, Chemokine, Receptor, CX3CR1, Chemokine receptor, Immunology, Cytokine, Stem cell