2015•Zhonghua shiyan yanke zazhiRequires access
Research progression of Fractalkine/cx3cr1 and microglia in retina diseases
Juanjuan Li
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Abstract
Fractalkine (Fkn) is the only member of CX3C subfamily of chemokine currently found, cx3cr1 is its specific receptor. Fkn/cx3cr1 is involved in inflammation, cancer, autoimmune diseases, allergy, acquired immune deficiency syndrome and other diseases, while its variety of pathophysiological role is accomplished by microglia. Functions of Fkn/cx3cr1 and microglia in age-related macular degeneration, acute light damage disease, retinal vascular disease, diabetic retinopathy disease, uveitis and other retina disease were reviewed in this article.
Key words:
Fractalkine; Cx3cr1; Microglia; Retina