Intravenous flurbiprofen axetil injection as a suppressant of agitation after functional endosoopic sinus surgery with sevoflurane general anesthesia

Objective To investigate the effects of the intravenously administra-tion of flurbiprofen axetil injection on agitation after functional endoscopic sinus surgery with sevoflurane general anesthesia. Methods A total of 40 patients aged from 18 years to 60 years in good health (ASA physical status Ⅰ～Ⅱ ) undergoing elective functional endoscopic sinus surgery were randomly and respectively divided into three groups. The patients were induced with fentanyl and propofol and rocuronium, and maintained with 2.5%～3.5% sevoflurane and oxygen. In group T, flurbiprofen axetil injection 50mg were administrated 15 minutes before the end of operation, and fentanyl 1μg/kg in group F, and in group C was given an equal volume of NS. The heart rate (HR), mean arterial blood pressure (MAP) were assessed during the anesthesia. The extubation time, waking time, postoperative agitation, nausea and vomiting were observed and recorded. Results The agitation was remarkably suppressed in group T and group F than group C. And there was a significant difference in mean heart rate and mean arterial blood pressure in group C compared with group T and F. And the extubation time and waking time were almostly the same in group T and group C, and both shorter than that in group F. The rate of nausea and vomiting were not increased in the group T. Conelusion It is safe and feasible to give flurbiprofen axetil injection 50mg to reduce agitation after functional endoscopic sinus surgery with sevoflurane general anesthesia. Key words: Flurbiprofen Axetil Injection;  Sevoflurane;  Agitation;  FESS