CLINICAL EXPERIENCE OF PARECOXIB AS A SUPPRESSANT OF AGITATION AFTER LAPAROSCOPIC OPERATION WITH SEVOFLURANE GENERAL ANESTHESIA AND OBSERVING THE UNTOWARD EFFECTS

Objective To investigate the effects of the parecoxib administration on agitation after laparoscopic operation with sevoflurane general anesthesia and observing the untoward effects.Methods A total of 90 patients aged from 18 years to 60 years in good health(ASA physical status Ⅰ-Ⅱ)undergoing selective laparoscopic surgery were randomly and double blindly divided into three groups.The patients were induced with midazolam,fengtanyl,vecuronium and propofol,and maintained with 2%~5% sevoflurane and oxygen.In group T,parecoxib 40 mg were administrated 30 minutes before the end of operation,and fentany 1ug/kg in group F,and in group C was given an equal volume of NS.The heart rate(HR),mean arterial blood pressure(MAP)were assessed during the anesthesia.The extubation time,waking time,postoperative agitation,nausea and vomiting were observed and recorded.Results The agitation was remarkably suppressed in group T and group F than group C.And there was a significant difference in mean heart rate and mean arterial blood pressure in group C compared with group T and F.And the extubation time and waking time were almost the same in group T and group C,both shorter than that in group F.The rate of nausea and vomiting did not increase in group T.Conclusion It is safe and feasible to give parecoxib 40mg to reduce agitation and untoward effect after laparoscopic operation with sevoflurane general anaesthesia.