Effects of propofol on plasma concentration of IL-6 and IL-10 in patients undergoing valve replacement during cardiopulmonary bypass

Objective To explore the effects of propofol on plasma concentration of IL-6 and IL-10 in patients undergoing valve replacement during cardiopulmonary bypass(CPB). Methods Thirty patients with rheumatic heart disease whose ASA scale were Ⅲ,aortic clamping time and CPB time were estimated more than 30 and 60 minutes respectively were selected and randomly divided into two groups:the control group(group C,n=15) and propofol group(group P,n=15). There were no differences between the two groups about medication during operation except that the propofol was used for anesthesia maintenance at the speed of 5 mg/(kg·h) in group P. Blood samples from superior vena cave were taken before operation (T1), 30 min after aortic clamping (T2), 90 min after discontinuation of CPB (T3) for detecting the plasma concentration of IL-6 and IL-10. Results The IL-6 levels of the two groups at T2, T3 were higher than that at T1(P<0.05), and the level at T3 achieved crest value. The IL-6 levels of group C at T3 were higher than T2(P<0.05), but there were no significant difference between T3 and T2 in group P. The IL-10 levels of the two groups showed to descend at T2 and to step up at T3, but there were significant difference only between T2 and T1 in group C(P<0.05), while there were significant difference between T3 and T2 in the two groups(P<0.05). The IL-6 and IL-10 levels of the two groups had no significant difference at T1 and T2, but at T3 the IL-6 levels in group P were higher than that in group C(P<0.05), at the same time the IL-10 levels in group P were lower than that in group C(P<0.05). Conclusions Propofol could inhibit inflammatory response by restraining the release of IL-6 and promoting the secretion of IL-10 during cardiopulmonary bypass. Key words: Propofol; Cardiopulmonary bypass;  Interleukin-6;  Interleukin-10;  Heart valve replacement