Influence of Different Dosage Propofol on Pulmonary Function in Patients with Cardiopulmonary Bypass

Objective To investigate the effects of different dosage of porpofol on pulmonary function in patients with cardiac valve replacement under cardiopulmonary bypass(CPB).Methods Total 42 patients with cardiac valve replacement under cardiopulmonary bypass(CPB) were randomly divided into group C,group P1 and group P2.In group P1 and P2,propofol were continuously injected with TCI after tracheal intubation till postoperation.No propofol was given in group C.The radial artery blood of all patients were collected at pre-CPB(T1),30 min post-lung reperfusion(T2),60 min(T3),120 min(T4),respectively.The blood gas,the concentrations of TNF-α,IL-6,Sicam-1 and MDA,the activity of SOD were measured.The P(A-a)O2 and RI were calculated based on the blood gas.Results Compared with T1,the P(A-a)O2 and RI in three groups from T2 to T4 were significantly increased(P0.05).Compared with group C,P(A-a)O2 and RI in propofol group were significantly decreased from T2 to T4(P0.05).Compared with P1 group,P(A-a)O2 and RI in P2 group were significantly decreased(P0.05).Compared with group C,the concentrations of TNF-α,IL-6,sICAM-1 and MDA in propofol groups were significantly decreased from T2 to T4(P0.05),and the concentration in P2 group were significantly less than that of P1 group(P0.05).Compared with group C,the activity of SOD in propofol groups were significantly increased(P0.05),and the activity in P2 group were significantly higher than that of P1 group(P0.05).Conclusion During CPB,propofol administration by TCI with 2 μg/mL and 4 μg/mL could relieve the pulmonary injury through inhibiting the release of inflammatory factors,reducing the production of oxygen free radical,increasing the capability of oxygen free radical clearing.The protective effects on pulmonary function was in a dose dependent manner.