Study of ~(18)F-SFDG PET/CT imaging in intericatal epileptogenic focus

Objective To explore the diagnostic value of ~(18)F-FDG PET/CT in qualitative and localizing analysis of epileptogenic foci during interictal period. Method Patient fasting 4-6 hours or more, fasting blood glucose 3.9～6. 1 mmol/L, elbow intravenous injection of imaging agent ~(18)F-FDG 0.12 mCi/kg,had 40 minutes calm rest, then did brain CT and PET3D tomography(slice thickness 3.75 mm). Dealing PET image with attenuation, proofing and iterative method to rebuild multi-section, multi-screen display. If naked eye could identify the radioactive changes(low metabolism,high metabolism areas) in more than two adjacent sections, the foci were confirmed. At the same time, according to data of radioactive tracer uptake of foci, semi-quantitative measurement was performed. For multiple epileptic foci, the comparison of SUVmax of focus and the same parts of contralateral site to the cerebellar SUVmax was performed. After craniotomy, acording to each patient's preoperative EEG, PET/CT results, the intracranial electrodes(cortical strip electrodes, deep brain electrodes) were set for monitoring the E EG of foci in order to prove ~(18)F-FDG PET/CT results. Results 37 foci were detected in 38 patients. The intraoperative EEG confirmed that the focus sites were accurate. One temporal lobe epilepsy case was not detected. Detection of single epileptogenic focus was more accurate than multiple epileptogenic foci. Conclusions ~(18)F-FDG PET/CT is a noninvasive, highly sensitive and effective method for epileptogenic focus positioning. Key words: Interictal period;  Epilepsy;  ~(18)F-FDG;  PET/CT