Study of intericatal ~(18)F-FDG PET in temporal lobe epilepsy

Objective To explore the value of directing to surgical teatment, qualitative and localizing epileptic foci of interictal 18 F FDG PET for temporal lobe epilepsy. Methods Interictal 18 F FDG PET brain imaging was perfrmed on 26 patients with normal CT or MRI. Their diagnosis of temporal lobe epilepsy were provde by clinical history and EEG. The imaging was analyzed by eyes and semi quantitative. The diagnostic specificity of 18 F FDG PET was evaluated by ECoG or depth electroencephalography during operation. 18 cased had been operated and followed up. 2 patients were excluded because of no finding epileptic foci, the other 7 cases were bilaterial temporal foci.Results The sensitivity of localizing epileptic foci by interictal 18 F FDG PET was 92%, and the specificity was 87%.Conclusions Interical 18 F FDG PET has high potenial ability in the detection of epileptic foci, but the accurate location of epileptic foci can't be confirmed only by the hypometabolistic area in 18 F FDG PET imaging. Combined 18 F FDG PET and ECoG would be of higher predictive value in the detection of epileptic foci. The localizing results of 18 F FDG PET in concordance with ECoG or DEEG was the hypothesis of complementary effect.