The clinical value of PET-CT 3D mode brain image on the localizing the epileptic foci

Objective To assess the value of 18F-FDG PET cerebral 3D mode on the localizing the epileptic foci.Methods 13 patients with epilepsy,The brain scans with 3D mode were performed in all the patients.The images were analyzed by eyes and semi-quantitative method by two experienced nuclear medicine physicians.The scalp electroencephalogram(EEG)was performed in all the patients.Among them,Electrocorticogram(EcoG) or depth electroencephalogram were performed in 2 cases to verify the results of PET.MRI and/or CT were obtained in 12 cases.Results In 13 patients,92.3% was abnormal displaying hypometabolic foci on PET imaging(12/13cases).PET was more sensitive than EEG and MRI/CT to detect the lesions(92.3%、69.2% and 33.3%℅ respectively,χ2 were 14.3 and 35.0,all P0.01).PET detected solitary lesion in 61.5% of patients,more higher than EEG(61.5% vs 38.4%,χ2 was 23.1,P0.01).Comparing with golden standard of EcoG or depth electroencephalogram,the sensitivity and specificity of PET to localize the epileptic foci were 95% and 89%.Conclusion 18F-FDG PET is a sensitive and accurate image modality on the localizing the epileptic foci.It is useful to direct surgical treatment and orientating radiation therapy.