The clinical significance of plasma tumor necrosis factor α and high sensitive T C-reactive protein in patients with coronary heart disease

Objective To explore the role of tumor necrosis factor a(TNF-α) and high sensitive Creactive protein (hsCRP) in mechanism of patients with coronary heart disease (CHD).Methods Ninety patients with diagnosed as angina pectoris by coronary angiography were selected our subjects.Among which,there were 46 cases with unstable angina pectoris (UAP group),44 cases with stable angina patients (SAP group).At the same time,30 cases with normal coronary angiography were selected and as control group.The level of TNF-α were measured by enzyme-linked immunosorbent assay,and the level of hsCRP was measured by immuno-nephelometry.Results The average plasma levels of TNF-α and hsCRP were (34.87 ± 9.59) ng/L,(2.34±0.81) mg/L in UAP group,significantly higher than those of SAP group ((25.39 ±7.68) ng/L,(1.79 ±0.59) mg/L; P ＜0.01),and both were higher than those of control group ((13.87 ± 5.24) nig/L,(1.15 ±0.35) mg/L;P ＜0.01).Conclusion Inflammatory might play an important role in the pathogenesis of CHD,and TNF-α and Hs-CRP show the significance in predicting occurrence of angina pectoris and development of CHD. Key words: Coronary heart disease;  Angina pectoris;  Tumor necrosis factorα;  C-reactive protein