The alteration and significance of plasma high sensitivity C-reactive protein and matrix metalloproteinase-9 in the patients with coronary heart disease

Objective To explore the role of high sensitivity C-reactive protein(hsCRP) and matrix metalloproteinase-9(MMP-9) in the mechanism of patients with coronary heart disease(CHD).Methods 70 patients with diagnosed as angina pectoris by coronary angiography were selected,among which there were 33 cases with stable angina patients(SAP group),37 cases with unstable angina pectoris(UAP group).At the same time,30 cases with normal coronary angiography were selected as control group.The level of hsCRP and MMP-9 were measured by immunonephelometry and enzyme-linked immunosorbant assay(ELISA),respectively.Results The mean plasma levels of hsCRP and MMP-9(2.95±0.62)mg/L,(24.29±4.73)mg/L in UAP group were significantly higher than those(1.83±0.57)mg/L,(19.83±4.63)mg/L of SAP group(P 0.01),and both were higher than those of control group(1.53±0.45)mg/L,(16.21±4.17)mg/L(P 0.05 or P 0.01).Conclusion Inflammatory mediators might play an important role in the pathogenesis of CHD,hsCRP and MMP-9 can reflect the stability of atherosclerotic plaque and the severity of coronary artery disease.