The expression and significance of plasma interleukin-6 and monocyte chemotactic factor-1 in patients with coronary heart disease

Objective To explore the role of interleukin-6(IL-6) and monocyte chemotaetic factor-1(MCP-1 ) in the mechanism of patients with coronary heart disease(CHD).Methods 70 patients who diagnosed as angina pectoris by coronary angiography were selected,among them,there were 36 cases with stable angina pectoris(SAP group),34 cases with unstable angina pectoris(UAP group).At the same time,30 cases with normal coronary angiography were selected as control group.The level of IL-6 and MCP-1 were measured by enzyme linked immunosorbant assay(ELISA),respectively.Results The mean plasma levels of IL-6 and MCP-1[(18.12±2.62) pg/L,(25.63±4.76) pg/L]in UAP group were significantly higher than those[(14.98±2.54) pg/L,(21.78±4.53) pg/L]of SAP group(P 0.01),and both were higher than those of control group[(11.68±2.51) pg/L,(15.71±4.34) pg/L,P 0.01].Conclusion Inflammatory mediators might play an important role in the pathogenesis of CHD,IL-6 and MCP-1 were more significant to refiect the stability of atherosclerotic plaque and the severity of coronary artery disease.