A study on efficacy and safety of fluoxetine combined with olanzapine in the treatment of major depression

Objective To assess the efficacy and tolerance of olanzapine and fluoxetine in the treatment of major depressive disorder without psychosis.Methods 73 outpatients with major depression were randomly assigned to olanzapine group and fluoxetine treatment group for 8 weeks.Hamilton Rating Scale for Depression (HAMD),Clinical Global Impression(CGI-SI)and Treatment Emergent Side-effect Scale(TESS)were used to evaluate efficacy and adverse effects respectively before and at the ends of 1,2,4,6,8 weeks treatment.Results There was a significant reduction in the HAMD-17scores from baseline to endpoint in both groups,but the olanzapine and fluoxetine group showed effect more quickly than fluoxetine group at 1,2,4,6weeks(P＜0.05)and its side effects were similar to the fluoxetine.Conclusion This study points to the potential of olanzapine and fluoxetine as a therapeutic agent for the treatment of major depressive disorder without psychosis. Key words: Major depression ;  Case-control study ;  Olanzapine ;  Fluoxetine ;  Efficacy ;