2019•Zhongguo jiceng yiyaoRequires access
Effect of enteral nutritional emulsion on nutritional status and immune function in patients with gastrointestinal tumor
Wei-Ping Ma, Jinli Li
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Abstract
Objective
To observe the effect of enteral nutritional emulsion on nutritional status and immune function in patients with gastrointestinal cancer.
Methods
From January 2014 to January 2017, 100 patients with gastrointestinal cancer in Yuncheng Central Hospital were selected in the research and randomly divided into two groups according to the digital table, with 50 cases in each group.All the patients underwent chemotherapy, the observation group was given enteral nutritional emulsion during chemotherapy.The indicators of nutritional status, immune function, the effect of chemotherapy, the incidence of adverse reactions were compared between the two groups.
Results
After treatment, the prealbumin, albumin, transferrin and hemoglobin levels in the observation group were (0.30±0.07)g/L, (32.93±1.67)g/L, (2.61±0.15)g/L, (109.94±2.31)g/L, respectively, which in the control group were (0.19±0.09)g/L, (30.89±1.49)g/L, (2.49±0.14)g/L, (108.07±2.04)g/L, respectively, there were statistically significant differences between the two groups(t=6.822, 6.445, 4.135, 4.291, all P<0.05). After treatment, the CD3+ , CD4/CD8, NK cells in the observation group were (43.84±7.65)%, (1.70±0.18) and (37.78±7.51)%, respectively, which in the control group were (36.12±6.57)%, (1.52±0.19) and (31.07±4.20)%, respectively, there were statistically significant differences between the two groups(t=5.413, 4.863, 6.124, all P<0.05). The objective response rate of the observation group (64%) was significantly higher than that of the control group(44%)(χ2=4.026, P<0.05). The incidence rate of adverse reaction of the observation group (18%) was significantly lower than that of the control group(36%)(χ2=4.110, P<0.05).
Conclusion
Enteral nutritional emulsion can effectively improve the nutritional status and immune function of patients with gastrointestinal cancer during chemotherapy, but also can effectively enhance sensitivity to chemotherapy, improve the effect of chemotherapy, and the safety is reliable.
Key words:
Gastrointestinal neoplasms; Gastrointestinal neoplasms; Fat emulsions, intravenous; Parenteral nutrition; Immune function; Nutritional status