Effects of parenteral nutrition in combination with chemotherapy on the nutritional status and immunity function in patients with malignant tumors of digestive tract

Objective To study the effect of parenteral nutrition combined with chemotherapy on nutritional status and immunity function of patients with gastrointestinal cancer. Methods 100 gastrointestinal cancer patients were treated as research subjects, and they were randomly divided into the treatment group and the control group. The control group was not given special treatment during chemotherapy,while the observation group patients were given nutritional support according to the gastrointestinal function after admission. The nutrition indicators of ALB,TF,PA,immune function parameters Ig A,IgG,Ig M,T lymphocyte subsets and T cell immune function indicators(CD4+,CD8+ and CD4+/CD8+)were counted after the four courses. Results There was no significant difference between the preoperative and after fourth courses of treatment(t=0.093,P>0.05)between the two groups in nutrition.Within group comparisons,data of Tf and PA levels in the observation group were significant different compared with the control group after fourth courses of treatment(t=3.302,P<0.05).After the first 4 postoperative course,IgM index was statistically significant(t=4.135,P<0.05)different between the two groups,three indicators within the observation group were higher than the preoperative level indicators,the difference was statistically significant(t=3.426,P<0.05).After the first 4 postoperative course,the CD4+ level was significantly higher in the observation group,the difference was statistically significant(t=0.087,P<0.05).Comparison between the two groups after the first four courses,the CD4+/CD8+ level was higher than that of preoperative patients with a significant difference(t=3.359,P<0.05).Intra-group comparison of the control group,four courses of CD8+ was significantly lower than that of the preoperative patients(t=3.265,P<0.05). Conclusion Parenteral nutrition combined with chemotherapy can improve the nutritional status of patients with malignant tumors of alimentary tract and improve the body's immune function, give parenteral nutrition support treatment and provide a theoretical basis for the digestive tract malignant tumor during chemotherapy.It is worthy of clinical popularization. Key words: Parenteral Nutrition; Antineoplastic combined chemotherapy protocols; Gastrointestinal neoplasms; Nutritional status; Immunity