Sedative effect of fentanyl combined with propofol on ventilated patients

Objective To investigate the role of propofol combined with fentanyl on the sedation in patients with mechanical ventilation.Methods Fifty patients were classified into two groups.One group was given propofol,the other one was given propofol and fentanyl.The goal was MAAS grade ≤3.The SBP,DBP,HR,R,SaO2,MAAS grade,in 4 hrs,8 hrs,24 hrs,and 48 hrs after the medicine were taken.The amount of propofol used,the fee,regain consciousness time and the satisfactory degree of sedation were recorded after taking medicine in 48 hrs.Results There were no significant differences of SBP,DBP,HR,RR,SaO2 between two groups at different time points(F=12.34,15.13,11.46,13.52,13.15,P0.05).After 8 hrs sedation treatment,the SBP was significantly decreased,while the SaO2 was significantly increased(t=8.22,13.11,12.53,9.12,PO.05).After 48 hrs treatment,the amount of propofol used in propofol combined with fetanyl group was less than those used in propofol group,and the regain consciousness time was also decreased.But the satisfactory degree of sedation was higher than that in group propofol(t=21.32,14.52;χ2=7.50,P0.05).Conclusions Propofol combined with fentanyl was a good therapeutic regimen for patient with consciousness by mechanical ventilation.