Analysis of esomeprazole combined with mosapride in the teatment of 76 cases with reflux esophagitis

Objective To observe the clinical efficacy of esomeprazole combined with mosapride in treatment of reflux esophagitis and to summarize the clinical experience.Methods 152 cases with reflux esophagitis were divided into observation group and control group according to the random number table extraction method,each group had 76 cases.The observation group was given esomeprazole combined with mosapride treatment and the control group was given omeprazole combined with mosapride.The clinical efficacy of the two groups were observed and compared after four weeks of treatment and after 8 weeks of treatment.Endoscopic reexamination esophagitis healing and adverse drug reactions were observed and compared after 8 weeks treatment.Results In the observation group after 4 weeks of treatment,total effective rate was 92.1％ (70/76),after eight weeks of treatment,total effective rate was 97.4％ (74/76).In the control group after four weeks of treatment,total effective rate was 81.6 ％ (62/76),after eight weeks of treatment total effective rate was 88.2％ (67/76).The total effective rate after 4 weeks and 8 weeks treatment between the two groups had significant differences (all P ＜ 0.05).Conclusion The clinical efficacy of esomeprazole combined with mosapride in treatment of reflux esophagitis is significantly better than the use of omeprazole and mosapride,it can effectively improve the symptoms of patients with gastroesophageal reflux,promote lesions healing as soon as possible,and have relatively minor adverse reactions,high security,worthy of promotion and use in clinical practice. Key words: Esomeprazole;  Mosapride;  Esophagitis, reflux;  Adverse reactions