The evaluation of biochemical parameters in diagnosis of liver disease

Objective To investigate the changes of biochemical parameters in liver disease. Methods Sernm contents of NAG, AFU, LAP, ASTm, GLDH,ADA, and CHE were determined with auto- biochemical analyzer and analyzed in 300 hepatitis patients and 30 healthy subjects. Results The mean values of LAP, ASTm, GLDH,ADA and AFU in acute hepatitis patients were significantly higher than control, positive rate were 93.0% 、81.0%、76. 0% 、82. 0% and 83.2% respectively;The mean values of ADA、AFU and NAG in liver cirrhosis patients were higher than control significantly, positive rate of were 88.5% 、38.2% and 94. 2% respectively;The mean values of ADA and NAG in severe hepatitis patients were higher than control significantly,positive rate are 64. 9% and 95.7% respectively; The mean values of LAP and NAG in liver cancer patients were higher than control significantly, positive rate were75.0% and 88.0% respectively. Conclusion The index of LAP and ASTm are valuable markers for diagnosing of acute hepatitis;The index of ADA, ASTm and CHE are valuable marker for diagnosing of liver cirrhosis;The index of ASTm, CHE, AFU and GLDH are valuable marker for diagnosing of severe hepatitis, and AFU and LAP are valuable markers for diagnosing of hepatocellular carcinoma. Key words: Liver disease; Liver enzymology; Liver function; Diagnosis