Study on diagnostic value of determination of liver enzymology in liver disease

Objective To evaluate the diagnostic value for the examination of liver enzymology in the patients suffering from liver diseases.Methods Serum values of NAG,AFU,LAP,ASTm,GLDH,ADA,AST,ALT,ALP,GGT,5'-NT and CHE were determined with auto-biochemical analyzer and analyzed statistically in 308 hepatitis patients and 115 healthy subjects.Results In acute hepatitis patients,the mean values of NAG,AFU,LAP,ASTm,GLDH,ADA,AST,ALT,ALP,GGT and 5'-NT increased significantly compared with healthy subjects.In liver cirrhosis patients,the mean values of NAG,LAP,ASTm,GLDH,ADA,AST,ALP,GGT and 5'-NT increased significantly while that of CHE decreased significantly compared with healthy subjects.In severe hepatitis patients,the mean values of NAG,AFU,ASTm,GLDH,ADA,AST,ALT,ALP,GGT and 5'-NT increased significantly while that of CHE decreased significantly compared with healthy subjects.In hepatocellular carcinoma,the mean values of NAG,AFU,LAP,ASTm,GLDH,ADA,AST,ALP,GGT and 5'-NT increased significantly while that of CHE decreased significantly compared with healthy subjects.Conclusion ALT,LAP,AFU,ASTm,AST and ALP are valuable markers for diagnosing acute hepatitis,ADA,AST,5'-NT,GGT and CHE are valuable marker for diagnosing liver cirrhosis,AST,ALT,ASTm,CHE,AFU and GLDH are valuable marker for diagnosing severe hepatitis,and AFU,5'-NT,GGT,ALP and LAP are valuable markers for diagnosing hepatocellular carcinoma.All items are less valuable for diagnosing chronic hepatitis and alcoholic hepatitis.