2018•Zhongguo jiceng yiyaoRequires access
High-risk human papillomavirus, thin-prep cytologic test combined with digital colposcopy cervical biopsy in the diagnosis of cervical intraepithelial neoplasia and cervical cancer
Hongxia Wei, Lijun Wei, Ruixia Zhao
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Abstract
Objective
To analyze the application of the HR-HPV, TCT combined with digital colposcopy cervical biopsy in diagnosis of CIN and cervical carcinoma.
Methods
From 2014 to 2016, 250 cases diagnosed as ASCUS and above the level of disease were selected in Shanxi Cancer Hospital, including 148 cases of ASCUS, 68 cases of LSIL, 27 cases of HSIL and 7 cases of SCC.The HR-HPV copy number was detected by using PCR fluorescence measurement, the Reid colposcopy scores were measured by using digital colposcopy, and the cervical histopathological diagnosis was regarded as a measurement rule.
Results
The diagnostic rate of simple use of TCT for the diagnosis of CIN and above lesions was 41.20%(103/250), HR-HPV & TCT in diagnosis of CIN and above lesions was 58.78%(77/131), TCT & digital colposcopy for the diagnosis of CIN and above lesions was 67.42%(89/132), which were significantly increased(χ2=35.87, P=0.00; χ2=59.01, P=0.00). The diagnostic rate of HR-HPV & TCT combined with electronic colposcopy in diagnosis of lesions above CIN was 79.82%(91/114), which was significantly higher than that of HR-HPV & TCT[58.78%(77/131)], and the diagnostic rate of TCT & digital colposcopy was 67.42%(89/132)(χ2=15.54, P=0.01; χ2=8.05, P=0.02). The incidence of CIN and cervical cancer were closely related with HR-HPV infection and the rate of HR-HPV infection showed an increasing trend with the aggravating degree of disease(the HR-HPV infection rate of ASCUS was 39.86%, the HR-HPV infection rate of LSIL was 61.76%, the HR-HPV infection rate of HSIL was 88.89%, while the HR-HPV infection rate of SCC was 100.00%).
Conclusion
HR-HPV, TCT combined with digital colposcopy can effectively improve the diagnosis rate of CIN and above the level of disease.At the same time, with the deterioration of the disease, HR-HPV infection rate increases significantly, which can provide diagnostic information and significance in the clinical diagnosis of CIN and cervical cancer.
Key words:
Human papillomavirus; Cytological techniques; Colposcopy; Biopsy; Cervical intraepithelial neoplasia