Application of the High-risk HPV Testing and Colposcopy in Diagnosing Atypical Squamous Cells of Undetermined Significance

Objective: To evaluate the application value of HR-HPV and colposcopy in CIN and invasive cervical cancer diagnosis,when ASCUS was diagnosed by the cervical cytology,and to build the clinical diagnose pathway.Methods:320 patients who were diagnosed as ASCUS underwent the colposcopy and HR-HPV test.The relationship between ASCUS and patients' age was also analysed.Results:In ASCUS patients,49.38% patients were aged from 30 to 49 years.The histo-pathological results of 320 ASCUS were as follows:inflammation 73.13%(234/320),condyloma 5.32%(17/320),CIN(included CINⅠ,CINⅡ,CINⅢ) 20.61%(66/320),high grade CIN(included CINⅡ,CINⅢ) and invasive cancer 7.5%(24/320).144 patients were HR-HPV positive,and the positive rate was 45%(144/320).In HR-HPV positive group,43.75% patients(63/144) were CIN.In HR-HPV negative group,only 3.41% patients(6/176)were CIN.Conclusions: Those ASCUS patients with HR-HPV positive,especially between 30-year to 49-year,should undergo colposcopy.Those patients with HR-HPV negative might not undergo colposcopy,but they should receive the TCT and HR-HPV test regularly.