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2011•International journal of pediatricsRequires access

Research advances in cord blood cytokine induced killer cells

Qiong Xiao

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Abstract

Cytokine induced killer (CIK) cells are immune effector cells generated from mononuclear cells induced by many cytokines. CIK cells have several advantages, such as rapid proliferation, broad spectrum killing activity, high tumoricidal activity and non-major histocompatibility complex restriction. Recently, cord blood derived CIK cells have attracted extensive concerns because of its faster proliferation, higher tumoricidal activity and lower incidence of GVHD compared with adult peripheral blood derived CIK cells. This paper will review the biological characteristics, clinical application and research advances of cord blood derived CIK cells. Key words: Cord blood;  Cytokine induced killer cells;  Immunotherapy

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What this paper is about

Cytokine induced killer (CIK) cells are immune effector cells generated from mononuclear cells induced by many cytokines. CIK cells have several advantages, such as rapid proliferation, broad spectrum killing activity, high tumoricidal activity and non-major histocompatibility complex restriction. Recently, cord blood derived CIK cells have attracted extensive concerns because of its faster proliferation, higher tumoricidal activity and lower incidence of GVHD compared with adult peripheral blood derived CIK cells. This paper will review the biological characteristics, clinical application and research advances of cord blood derived CIK cells. Key words: Cord blood;  Cytokine induced killer cells;  Immunotherapy

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Available abstract

Cytokine induced killer (CIK) cells are immune effector cells generated from mononuclear cells induced by many cytokines. CIK cells have several advantages, such as rapid proliferation, broad spectrum killing activity, high tumoricidal activity and non-major histocompatibility complex restriction. Recently, cord blood derived CIK cells have attracted extensive concerns because of its faster proliferation, higher tumoricidal activity and lower incidence of GVHD compared with adult peripheral blood derived CIK cells. This paper will review the biological characteristics, clinical application and research advances of cord blood derived CIK cells. Key words: Cord blood;  Cytokine induced killer cells;  Immunotherapy

Key concepts: Cytokine-induced killer cell, Medicine, Cord blood, Peripheral blood mononuclear cell, Immunology, Cytokine, Immune system, Immunotherapy

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