Postoperative intravenous analgesia with butorphanol combined with fentanyl in patients under-went thoracic surgery

Objective To evaluate the efficacy for patient controfled intravenous analgesia(PCIA) of butorphanol combined with fentanyl in the patients underwent thoracic surgery .Methods Ninety ASA I --1I patients scheduled for elective thoracic surgery under general anesthesia were randomly allocated into three groups,each group including 30 patients.Group B received butorphanol O.15 mg/ml,group F received fentanyl 20μg/ml,group BF received butorphanol 0.1 mg/ml combined with fentanyl 10μg/ml.PCIA was initiated just before the beginning of skin suturing with a loading dose of 1 ml,continuous rate was 1 ml/h,bolus was 0.5 ml,and lockout time WaS 10 minutes.VAS,sedative scores,respiratory frequency,saturation of blood oxygen,press times,pain-killer dose,side effects and satisfaction to analgesia at 1,4,8,12,24 and 48 hours after operation were recorded. Results VAS in group B WaS significandy higher than that in group F and group BF at 1,4,8 and 12 hours after operation(P＜0.05),and there WaS no significant differ-ence betweengroup Fand group B F(P＞0.05).Thesedative scoresin group B and B Fwere higherthanthat in group F,but no excess sedation WaS found in the former two groups.At the same time,the satisfaction to analgesia was the lowest in group B,the highest in group BF and higher in group F.There were no incidence of nausea,vomiting and pruritus in group B and group BF,but pruritus WaS 16.7%and nausea,vomiting was 23.3%in group F.Conclusions Butorphanol combined with fentanyl Can improve analgesia efficacy and reduce fentanyl adverse incidence.It Can provide the better balance between pain relief and side effects after thoracic surgery. Key words: Analgesia,patient-controlled; Thoracic surgical procedures;  Butorphanol; Fentanyl