Clincal Effect of Butorphanol Combined with Fentanyl on Postoperative Pain Relief with Intravenous Patient Controlled Analgesia

Objective To compare the analgesic effects of butorphanol,fentanyl and butorphanol combined with fentanyl for postoperative patient-controlled intravenous analgesia(PCIA).Methods Sixty ASA class Ⅰor Ⅱpatients undergoing abdominal operations were randomly assigned into three groups with 20 cases each.The patients in group B received butorphanol(0.2mg/mL,in group F fentanyl(10 ug/mL),and in group BF butorphanol(0.1 mg/mL)with fentanyl(5 ug/mL)for PCIA.The PCA model for all groups was set with background infusion 2 mL/h,bolus of 1ml with lock time 15 min.The visual analogue scale(VAS)analgesic score,Ramsay sedation score and side effects were recorded and compared among three groups at 2,4,8,18,24,48 h after the operations.Results Adequate analgesia was achieved in all three groups.VAS score of group BF was significantly lower than that of group B at 8,18,24 h after the operation(P0.05).Ramsay sedation score of group B was significantly higher than that of group F at 4,8,18,24h after the operation(P0.05).The incidence of dizziness of group B was significantly higher than that of group F(P0.05).The incidence of postoperative vomiting of group BF was significantly lower than that of group F(P0.05).Conclusion Butorphanol combined with fentanyl for postoperative intravenous analgesia shows effective analgesia with fewer side effects,which is good mixture for PCIA.