2011•Zhonghua neifenmi daixie zazhiRequires access
Vaspin,obesity,and type 2 diabetes
Shiwei Liu, Jing Yang
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Abstract
Vaspin,a serine protease inhibitor derived from visceral adipose tissue,has been identified as an adipokine with insulin-sensitizing effects in a rat model of type 2 diabetes.Recent studies showed that the administration of recombinant human vaspin significantly improved insulin sensitivity and glucose tolerance,and reversed the expression of genes that may promote insulin resistance in diet-induced obese mice.However,the regulation of serum vaspin concentration in individuals with insulin resistance,and the association of vaspin with obesity,type 2 diabetes,and insulin resistance related disorders remain unclear.
Key words:
Adipokine; Vaspin; Obesity; Diabetes mellitus,type 2; Insulin resistance