Effect of small dose of dexmedetomidine on the quality of general anesthesia in patients with hypertension

Objective To explore the effects of dexmedetomidine on recovery quality of hypertension patients under general anesthesia, so as to provide reference for its clinical application. Methods 31 patients who underwent abdominal surgery were chosen as study subjects. They were randomly divided into observation group(15 patients) and control group(16 patients) according to the digital table. At the time of 15 min before the end of surgery, the patients in the observation group were injected with dexmedetomidine of 0.5g/kg, and the patients in the control group were injected with the same volume of normal saline instead in 15 min. At the time of before anesthesia(T0), before injection(T1), 3 min after injection (T2), just before extubation(T3), 1 min(T4), 5 min(T5), 15 min(T6) after extubation, the hemodynamic parameters, the sedation scores at the time of T5 and T6, and the occurrence of cough during extubation were recorded and compared between the two groups. Results During operation and extubation, the levels of SBP, DBP, HR and their fluctuations in the observation group were lower than those in the control group. At the time of T5 and T6, the sedation scores in the observation were lower than those in the control group. The mean rank and scores of the two groups [at the time of T5 were [(12.2±24.6) and (19.5±24.6), respectively, Z=2.27, P=0.022]. The mean rank and scores of the two groups at the time of T6 were T6[(12.3±24.7) and (19.5±24.7), respectively, Z=2.25, P=0.024]. During the time of extubation, the occurrence of cough in the observation group was lower than that in the control group. The mean rank of the cough score in the observation group and the control group was[ (12.2±24.1) and (19.5±24.1), Z=2.33, P=0.020]. Conclusion Small dose of dexmedetomidine can reduce the incidences of intraoperative cerebral vascular accident risk, improve the quality of general anesthesia recovery in hypertension patients, and thus should be recommend in clinical application. Key words: Hypertension; Anesthesia, general; Dexmedetomidine