Effect of dexmedetomidine on anesthesia recovery in gynecological laparoscopic operation

Objective To investigate the effect of dexmedetomidine on anesthesia recovery in gynecological laparoscopic operation.Methods Sixty cases of patients underwent gynecological laparoscopic operation with ASA Ⅰ-Ⅱ were randomly divided into two groups:dexmedetomidine group(group A) and normal saline control group(group B) with 30 cases in each group.Patients in group A were given 0.5 μg/kg dexmedetomidine infusion for 10 min after tracheal intubation but before operation.Patients in group B were given the same dose of normal saline.The mean arterial pressure(MAP),heart rate(HR),saturation of pulse oximetry(SpO2),narcotrend index(NI) and ramsay sedation score in each group were recorded before administration(T1),at the time of extubation(T2),5 min(T3),10 min(T4) and 15 min(T5) after extubation.The time until drug withdrawal to consciousness and the time of pulling out laryngeal mask airway were recorded.And the adverse effects during recovery period after extubation were also recorded,such as respiratory depression,postoperative irritability,nausea and vomit.Results There was no significant difference between the two groups in extubation time and consciousness time(P 0.05).In group A,the MAP and HR at T2 was significantly higher than that at T1,and that at T3-T5 was lower than that at T1.The MAP and HR at T3-T5 in group A was significantly higher than that in group B,NI and Ramsay score in group A was better than that in group B.And respiratory depression,postoperative irritability,nausea and vomit,and other adverse reactions in group A were significantly lower than that in group B.Conclusion Dexmedetomidine used in gynecological laparoscopic operation can stabilize haemodynamics during the period of induction of anesthesia,intubation and extubation.And it does not influence the breath,consciousness recovery and extubation condition in recovery period.So it can be safely applied in clinic.