Hemodynamic effects of low dose continuous dexmedetomidine infusion on patients with hypertension undergoing general anesthesia

Objective To study the hemodynamic effects of low dose continuous dexmedetomidine infusion on patients with hypertension undergoing general anesthesia.Methods A total of 40 patients with hypertension,scheduled for thyroidectomy under inhalational combined with intravenous anesthesia,were randomly divided into two groups.Group D received 0.3μg·kg-1·h-1of dexmedetomidine intravenously for 10 minutes before surgery.Group C received the same volume of 0.9%saline.During maintenance of anaesthesia,BIS were maintained between 40-50.SBP,DBP and HR were recorded at entering operating room(T0),1 min before intubation(T1),2 min after intubation(T2),2min after skin incision(T3),extubation(T4)and entering PACU(T5);and Ramsay scores,VAS pain scores were compared at 5min after entering PACU.Results HR was significantly diminished at T4 compared with T0(P0.05)in two group,and the SBP,DBP in group C were significantly higher than in group D at T1,T2(P0.05).The use rate of antihypertensive agents in group C was significantly higher than in group D(45%vs.10%,P0.05).Ramsay sedation scores in group D was higher than in group C at T5(P 0.05).Conclusion Low dose continuous dexmedetomidine infusion for patients with hypertension can provide more satisfactory sedative,and analgesia effects without complications.