The relation between hemorrheology and platelet activation in patients with chronic cor pulmonary

Objective To investigate the relationship among hemorrheology and platelet membrane glucoproteins (GP Ⅱ b/Ⅲ a and P-selectin) in patients with chronic cor pulmonary. Methods Subjects were divided into 2 groups (46 elderly patients with cor pulmonary,36 cases of healthy subjects). Hemorrheology was determined, and positive rates of GP Ⅱ b/ Ⅲ a and P-selectin were measured with tricolor flow cytometry. Results Compared with healthy group, blood viscosity and the expressions of both GP Ⅱ b/ Ⅲ a、 P-selectin were increased significantly in patients with chronic cor pulmonary (all P<0.05). There was a positive correlation between the GP Ⅱ b/ Ⅲ a、P-selectin and the blood viscosity and fibrinogenin patients with chronic cor pulmonale.Conclusion The platelet in patients with chronic cor pulmonary is at the overactivated state,the blood has the pathologio change of mucosity, thickness and there is a relation between activated platelet and hemorrheology. Key words: Chronic cor pulmonary; Platelet activation; Hemorrheology; Flow cytometry