Relationship between Platelet Activation and Cor Pulmonale

Objective To investigate the relationship between the platelet activation and cor pulmonale. Methods Plasma concentration of platelet\|activating markers CD\-\{62P\} and P\-\{10\} on platelet surface were assayed using ELISA and FCM, patient's blood gas and pulmonary functions were also analysed. Results The patients of cor pulmonale had abnormal platelet activation, as compared with that in control, with remarkable difference(P0.01). The level of plateler activation was negatively related with that of PaO\-2 and pulmonary functions significantly. Conclusion There is an abnormal platelet activation in cor pulmonale, especially when the condition worsened. It is valuable to treat cor pulmonale using platelet activation controlling drug and coagulant.\;