2017•Zhongguo jiceng yiyaoRequires access
Application of CD10, desmin and vimentin in differential diagnosis of special types of uterine tumors
Li Li, Zhaojun Wang, Huajing Zhang, Pengfei Dou, Tengzhou Zhang
Open publisher page 0 citations
Abstract
Objective
To study the application value of CD10, desmin and vimentin in the diagnosis and differential diagnosis of special types of uterine tumors.
Methods
The clinical data of 79 cases of special types of uterine cancer were retrospectively analyzed.CD10, desmin and vimentin were detected respectively by immunohistochemical streptavidin-perosidase(SP) method.
Results
The positive rates of CD10 in endometrial stromal sarcoma, epithelioid leiomyoma, atypical leiomyoma, leiomyosarcoma, carcinosarcoma were 76.2%, 0.0%, 13.3%, 30.8%, 75.0%, respectively.The positive rates of vimentin in endometrial stromal sarcoma, epithelioid leiomyoma, atypical leiomyoma, leiomyosarcoma, carcinosarcoma were 100.0%, 5.6%, 0.0%, 46.2%, 83.3%, respectively.The positive rates of desmin in endometrial stromal sarcoma, epithelioid leiomyoma, atypical leiomyoma, leiomyosarcoma, carcinosarcoma were 0.0%, 61.1%, 53.3%, 30.8%, 0.0%, respectively.The positive rates of vimentin and CD10 in endometrial stromal sarcoma and carcinosarcoma were all significantly higher than those in atypical leiomyoma, epithelioid leiomyoma(CD10: χ2=23.255, 13.829, 15.880, 8.102, all P=0.000; vimentin: χ2=35.159, 36.000, 15.556, 16.440, all P=0.000). The positive rates of desmin in atypical leiomyoma, epithelioid leiomyoma tissues were significantly higher than those in endometrial interstitial sarcomas, carcinosarcoma(χ2=11.480, 6.717, 17.875, 9.097, all P=0.000).
Conclusion
CD10, desmin and vimentin can be used as sensitive indicators for the differential diagnosis of uterine tumors with special types.
Key words:
Uterine neoplasms; CD10; Desmin; Vimentin; Diagnosis, differential