2009•Zhonghua zhongyiyao zazhiRequires access
Effect of BaoYuan II on expression of Smad in kidney of diabetic rat.
Qing Li, Zhang He, Zhenhua Ding, Yan HuiMing
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Abstract
Objective: To observe the expression of Smad in diabetic rat’s kidney and the effect of BaoYuan II to it.Methods: SD rats were randomly divided into four groups: control group,model group,Benazepril-treatment group and BaoYuan II-treatment group.The latter three groups were induced to be diabetic nephropathy by intraperitoneal injection with streptozotocin and then the drugs were treated respectively.After eight weeks,the plasma albumin,blood glucose,urinary protein,urinaryβ2-M were determined and expression of mRNA of TGF-β1,Smad2,Smad3,Smad7 was detected by RT-PCR.Results: Compared with diabetic rats group,the level of plasma albumin was increased and the level of blood glucose,urinary protein,urinaryβ2-M was depressed in BaoYuan II-treatment group.The expression of TGF-β1 and Smad2,Smad3 were down-regulated and Smad7 was up-regulated in model group.The effects of BaoYuan II were similar to Benazepril.Conclusion: BaoYuan II had protected effect to diabetic nephropathy rats.It acted by regulating TGF-β1 and Smad2,Smad3,Smad7 possibly.