Effect of Extract Black Cumin (Nigela Sativa) on the LDL/HDL Ratio of Ovariectomized White Mouse (Rattus Novergicus Strain Wistas)

Changes in fat metabolism by estrogen deficiency is one of the factors \nincreasing the risk of CHD in postmenopausal women. Black cumin (Nigella sativa) is \na spice that can be used as a medicinal plant. From several studies, Nigella sativa could \nshow the effects of estrogen. Objective: to determine the effect of black cumin \n(Nigella sativa) against changes on LDL/HDL ratio of the ovariectomized white mouse \n(Rattus novergicus wistar strain) Method : True Experimental design with the post test \nonly control group design with 25 female mouse divided into five groups : 2 controle \ngroup positive and negative, and 3 treatment groups of black cumin extract at a dose of \n1.25, 2.5 and 5 mg/kg BW /day. Results : One way ANOVA test showed the non \nsignificant value (p > 0.05) of weight changes (p: 0.055), HDL level (p : 0.326) and \nLDL level ( p: 0.659). At Kruskal-Wallis test showed the non significant value of \nLDL/HDL ratio (p : 0.152 (p > 0.05)). Conclusion : Extract of black cumin (N. sativa) \ncould not significant affect on LDL/HDL ratio of the ovariectomized white mouse \n(Rattus novergicus wistar strain)