Studies on effect of Cumin extract on induced hyper cholesteraemic male rats

In the present study, the effect of water extract of cumin on plasma lipids were studied in healthy male rats. The objective of the present research is to study the effect of extract of cumin on plasma lipids and lipoproteins in induced hyper cholesterolemic male rats. Various biochemical parameters such as triglycerides (TG), total cholesterol (TC), HDL-C and LDL-C were studied. The body weight of rats was measured before and end of the experiment. The results of present study shows that water extract of cumin cause significant decrease of TC (pre- test 299+-37.08, post-test 149.1+-31, p=0.017) and LDL-C(pretest 153+-14 ,post-test 0.12+-8.7, p=0.001). While in case of feeding groups of water extract of cumin shows significant increasing levels of HDL-C(pre-test 77+-13.1 , post-test 120+-18, p=0.003) . No changes in the body weight of the rats were observed in exercised group. Significant changes were also noticed in rats treated with cumin extract.