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[Study on HPLC fingerprint of Prunella vulgaris].

Weiguang Sun, KE Xue-hong, Yuan Li, Ru-Feng Hua, Jinfu Chen

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Abstract

OBJECTIVE: To establish HPLC fingerprint of Prunella vulgarise for quality control of the herbal medicine. METHOD: A sunfire C18 analytical column was used. The mobile phase A was 1% acetic acid, and mobile phase B was methanol. The elution was in gradient mode and detection wavelength was set at 290 nm. The flow rate was 1.0 mL x min(-1) and the column temperature at 30 degrees C. The analysis time was 60 min. RESULT: The similarity of 10 batches of P. vulgaris was not lower than 0.810. The fingerprints of the herbal medicine were classified P. vulgaris on the results of cluster analysis. CONCLUSION: This method is available for quality evaluation and control the quality of P. vulgaris.

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What this paper is about

OBJECTIVE: To establish HPLC fingerprint of Prunella vulgarise for quality control of the herbal medicine. METHOD: A sunfire C18 analytical column was used. The mobile phase A was 1% acetic acid, and mobile phase B was methanol. The elution was in gradient mode and detection wavelength was set at 290 nm. The flow rate was 1.0 mL x min(-1) and the column temperature at 30 degrees C. The analysis time was 60 min. RESULT: The similarity of 10 batches of P. vulgaris was not lower than 0.810. The fingerprints of the herbal medicine were classified P. vulgaris on the results of cluster analysis. CONCLUSION: This method is available for quality evaluation and control the quality of P. vulgaris.

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Available abstract

OBJECTIVE: To establish HPLC fingerprint of Prunella vulgarise for quality control of the herbal medicine. METHOD: A sunfire C18 analytical column was used. The mobile phase A was 1% acetic acid, and mobile phase B was methanol. The elution was in gradient mode and detection wavelength was set at 290 nm. The flow rate was 1.0 mL x min(-1) and the column temperature at 30 degrees C. The analysis time was 60 min. RESULT: The similarity of 10 batches of P. vulgaris was not lower than 0.810. The fingerprints of the herbal medicine were classified P. vulgaris on the results of cluster analysis. CONCLUSION: This method is available for quality evaluation and control the quality of P. vulgaris.

Key concepts: Prunella vulgaris, Gradient elution, Chromatography, High-performance liquid chromatography, Fingerprint (computing), Chemistry, Computer science, Medicine

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