2011•Journal of Hebei North UniversityRequires access
Effect of Kangnaoye on Contents of SOD and MDA in Heart and Brain Tissue During Cerebral Ischemia-reperfusion in Rats
Qian Xue
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Abstract
Objective To observe the effects of Kangnaoye on contents of SOD and MDA of heart and brain tissue in rats during cerebral ischemia-reperfusion in order to study the neuroprotection and its possible mechanism of Kangnaoye.Methods 36 rats were randomly divided into 6 groups,which were sham-operation grop,ischemia-reperfusion group,Kangnaoye groups with high high dose,medium dose and low dose,and edaravone grop.The model of cerebral ischemia-reperfusion were established by the method of MCAO.The content of SOD and MDA in heart and brain tissue were measured 24h after reperfusion.At the same time,the changes of pathomorphology of brain tissue were observed.Results Compared of with that ischemia-reperfusion group,SOD activities were increased significantly,MDA content were decreased significantly in Kangnaoye groups(P0.05~0.01).Conclusion Kangnaoye shows protective effects on cerebral ischemia-reperfusion.The mechanism may be ralated to improving neuronal protection and anti-oxyradical effects.