1997•Carcinogenesis,Teratogenesis and MutagenesisRequires access

The genotoxicity study of CHCL_(3) and CCI_(4) using micronucleus test in Vicia Faba root tip cells

Zhiyu Jin, Songke Ma, Yang Rudao

Abstract

The genotoxicity and interaction of CHCI_(3) and CCI_(4) were analyzed by micronucleus test in Vicia Faba root tip cells. CHCI_(3)(0.503-50.302μmol/L) and CCI_(4) 0.0195-1.9501μmol/L)significantly induced micronuclei in the Vicia Faba cells(P<0.01),respectively. A significant dose-response was found. A significant effects on micronucleus induction and interaction were observed when the solution containing 2 chemicals was used to treat the Vicia Faba cells. 2 chemicals showed some antagonistic effect. The results indicated that CHCI_(3) and CCI_(4) possess significant genotoxicity. The safety of maximum acceptable concentraton of CHCI_(3) and CCI_(4) in drinking water,was also discussed.

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Key concepts: Vicia faba, Micronucleus test, Genotoxicity, Micronucleus, Root tip, Chemistry, Positive control, Vicia