2007•Unpublished venueRequires access
Clinical Effect of Metoprolol on Elderly Patients with Chronic Heart Failure and its Safety
Pla N
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Abstract
Objective To evaluate the clinical effect of metoprolol on elderly patients with chronic heart failure and its safety.Methods A total of 107 elderly patients with chronic heart failure were allocated into metoprolol group(n=53) and control group(n=54) at random.The patients in the metoprolol group were treated with metoprolol(12.5-25mg,twice per day) and the patients in the control group were only given routine treatment without metoprolol.The changes in heart rate,blood pressure,heart function and echocardiography were observed before and after treatment.Results The effective rate and total effective rate in the metoprolol group were 53.7% and 88.6%,and the counterparts were 30.3% and 67.8% in the control group,respectively(P0.05).After the treatment lasting months,not only the heart rate and the blood pressure in the metoprolol group were lower than that in the control group,but the heart function and the indexes of echocardiography(LVEF,LVDD) were obviously improved as well.Conclusion Metoprolol can served as an effective and safe agent for the treatment of the elderly patients with chronic heart failure.