2009•Xinxueguan kangfu yixue zazhiRequires access
Therapeutic effect of metoprolol in patients with chronic congestive heart failure
Zhou Jin-hui
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Abstract
Objective:To study the therapeutic effect of metoprolol in patients with chronic congestive heart failure.Methods:A total of 72 patients with congestive heart failure(CHF)were randomly divided into routine therapy group(control group,34 cases,treated with routine therapy)and metoprolol group(38 cases,treated with metoprolol above the base of therapy in control group).The metoprolol start dose was 0.25mg,increased dose every two weeks,until 50mg,two timesd and continued three months in metoprolol group.Results:The excellence rate was 44.7%,and the total effective rate was 89.4% in metoprolol group,its were more than those of control group(26.5%,64.7%,P0.05).The heart rate,blood pressure,left ventricular ejection fraction(LFEF)and left ventricular end-diastolic dimension(LVEDD)significantly improved after therapy in metoprolol group,the improve of heart rate,blood pressure and LVEF were more than those of control group(P0.05).Conclusion:Therapeutic of metoprolol above the routine therapy is effective and safety,may improve cardiac ventricular remodeling.