The Relationship between Fibrinogen,LP(a) and Carotid Atherosclerosis in Cerebral Infarction Patients

Objective To evaluate the relationship between fibrinogen(Fib),lipoprotein(a) and carotid atherosclerosis in cerebral infarction patients.Methods 130 patients with cerebral infarction underwent carotid artery duplex ultrasonography to detect the intima-media thickness(IMT) and the plaque formation of the common carotid arteries.Blood sample was drawn to evaluate the concentration of FIB and Lp(a).Results There were 76 patients with carotid atherosclerosis disorders,29 of them were increased IMT and 47 cases with carotid atherosclerosis plaque.The average levels of FIB and Lp(a) were significantly higher in patients with carotid atherosclerosis disorders than those without carotid atherosclerosis disorders(both P0.01).The increase in the incidence of carotid atherosclerosis plaque was significantly associated with the increase of levels of FIB and Lp(a)(both P0.05).Conclusions Plasma levels of FIB and Lp(a)are strongly associated with carotid atherosclerosis in patients with cerebral infarction.