2011•Journal of Apoplexy and Nervous DiseasesRequires access
The expression of connexin32 within the procerebrum of the epilepsy rats induced with Kainic acid and interventional influence of octanol
Ling Huang
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Abstract
Objective To observe the expression of connexin32 within the procerebrum of the epilepsy rats induced with Kainic acid and interventional influence of octanol.Methods The expression of CX32 positive cells at different time points in cortex and hippocampus of the epilepsy rats induced with Kainic acid was detected by immumoflourescence method.Meanwhile,the effects of octanol intervention on the expression of CX32 positive cells in cortex and hippocampus of rat brain administered before epilepsy was evaluated.Results The expression of CX32 positive cells in cortex and hippocampus in the group of epilepsy-rats induced by kainic acid was higher than that in normal control group at different time points(P0.05),and increased gradually,reached peak on 7d.The change in hippocampus was more obvious than in cortex.However,there was no significant difference(P0.05).The expression of CX32 positive cells in cortex and hippocampus in the group intervened by octanol was lower than that in the group of epilepsy-rats induced by kainic acid at corresponding time points(P0.01).Conclusions The results indicate that gap junction via CX32 may play an important role in the occurrence and development of epilepsy.Octanol could reduce the expression of CX32 in procerebrum of the epilepsy rats,decrease susceptibility of epilepsy and implement protection of brain.