2008•Journal of Apoplexy and Nervous DiseasesRequires access
The expression of connexin43 within the hippocampus of the epilepsy rats and the protective effects of carbenoxolone
Ping Ji
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Abstract
Objective To study the relationship between the expression of connexin43 within the hippocampus astrocyte of the adult rats and pathogenesis of epilepsy and the influence of carbenoxolone on the expression of CX43 as gap junction antagonist.Methods The expression of CX43 in different time points in hippocampus astrocytes of rat brain was investigated by immunohistochemistry.Meanwhile,the effects of different dose of carbenoxolone on the expression of CX43 in hippocampus astrocytes of rat brain administered before epilepsy was evaluated.Results The basic sporadic expression of CX43 in hippocampus astrocytes could be observed in control group rats.The expression of CX43 could be observed in the epilepsy group rats 1h after epilepsy,and increased gradually,reached peak in 72 hours.The expression of CX43 in hippocampus astrocytes of rat brain in each carbenoxolone group was less(P0.01)than that in the epilepsy group rats(P0.01),and was downregulated as the dose of carbenoxolone increased(P0.01).Conclusion There is strong correlation between the expression of connexin43 in hippocampus astrocyte of epilepsy rats brain and the the pathogenesis of epilepsy.The gap junction antagonist carbenoxolone affected the expression of connexin43 in rat brain,and plays positively neuroprotective effects.