2009•Journal of Apoplexy and Nervous DiseasesRequires access
Protection of octanol on epilepsy-rats induced by kainic acid and the effects on the expression of connexin43 in hippocampal tissue
Jianmin Huang
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Abstract
Objective To study the effects of octanol on the expression of connexin 43 in the brain of epilepsy-rats induced by kainic acid and the anti-epileptic effect of octanol.Methods The epilepsy-rats induced by kainic acid and treated by octanol was assessed by behavior score.The expression of CX43 in the hippocampal tissue was measured by immunohistochemistry.Results The expression of CX43 in the group of epilepsy-rats induced by kainic acid was higher than that in control group( P 0.01);the expression of CX43 in the group treated by octanol was higher than that in control group( P 0.01),but lower than the group of epilepsy-rats induced by kainic acid;the Patel score of the rats in the group treated by octanol was lower than the group only induced by kainic acid within 3 hours after the induction ( P 0.01),and the latency was longer ( P 0.01).Conclusions After the epileptic seizure repeatedly,the expression of CX43 was upregulated.Octanol could reduce the expression of CX43,decrease the Patel score,and extend the latency of epileptic seizure.It has obviously anti-epileptic effect.