Continuous Subcutaneous Infusion of Insulin Lispro for Elderly Patients with Type 2 Diabetes

Objective: To compare the efficacy and safety between the insulin lispro on the continuous subcutaneous insulin infu-sion(CSII) and insulin multiple daily injection in treatment of elderly patient with type 2 diabetes(T2DM) who were poorly controlled.Methods: A total of 58 elderly T2DM patients were divided randomly into two groups.Observation group(29 cases) received CSII(Re-combinant Human Insulin Lispro injection) and control group(29 cases) received conventional insulin subcutaneous injection(Mixed Protamine Zinc Recombinant Human Insulin Lispro Injection(25R)),twice a day.Both were given diabetes education,diet control for 2 weeks.The blood sugar,insulin dosage,duration of normal glucose and incidence of low blood sugar were compared between 2 groups before treatment and after.Results: After treatment,the fasting blood sugar and 2h postprandial glucose were decreased.Observation group was much lower than control group(P0.05).The duration of normal glucose of observation group was shorter than that of control group(P0.05).The total daily insulin dosage in observation group were smaller than that in control group.There was no significant difference in low blood sugar between the two groups.Conclusion: Insulin lispro on the continuous subcutaneous insulin infusion is an effective agent for good glucose control with fewer hypoglycemic episodes in the elderly patient with type 2 diabetic patient.