Preventive Effect of Tropisetron on Postoperative Nausea and Vomiting during Patient-Controlled Analyesia after Uterectomy

Objective To compare the preventive effects of tropisetron in different administrations on postoperative nausea and vomiting during patient-controlled analgesia with tramadol after uterectomy.Methods One hundred and twenty ASA classⅠ～Ⅱ uterectomy patients were divided into 3 groups:group A,group B and group C,forty cases in each group.In group A,patients were given tropisetron 6 mg IV injection only,patients in group B were given tropisetron 3 mg IV injection and tropisetron 3 mg in PCA pump,patients in group C were given tropisetron 4 mg in PCA pump.Nausea and vomiting were recorded in different periods(0～1 h,1～3 h,3～6 h,6～12 h,12～24 h,and 24～48 h) during PCA.Results In group A and group B,the incidences of vomiting at 2 h,4 h and 8 h after operation were reduced significantly compared with group C(P0.05).The incidence of vomiting was reduced significantly in group B compared with group A at 48 h after operation(P 0.05).Conclusion The asministration of tropisetron by intravenous injection and PCA pump after operation has better preventive effects in reducing the incidence of postoperative nausea and vomiting during patient-controlled analgesia than other asministrations.