Related Risk Factors of Acute Respiratory Distress Syndrome Induced by Mechanical Ventilation

Objective To explore the related risk factors of acute respiratory distress syndrome(ARDS) as complication after mechanical ventilation so as to provide the reference for improvement of diagnosis and prevention of ARDS induced by mechanical ventilation. Methods A total of 148 inpatients underwent mechanical ventilation for more than 48 hours were recruited from December 2005 to June 2010 in our hospital.The patients were divided as ARDS group(n=121) and non-ARDS group(n=27) according to whether they got ARDS during 48 hours mechanical ventilation.The data of the patients between the two groups were comparatively statistically analyzed,including patients′ age,sex,admission etiology,SAPS score,tracheotomy,oxygenation index(PaO2/FiO2),pH value,peak inspiratory flow(PIF),pulmonary compliance,PaCO2,PaO2,positive end-expiratory pressure(PEEP),activated partial thromboplastin time(APTT),respiratory rate,red blood cell count,creatinine,and glucose. Results The results of comparatively statistically analyses showed that there were no statistical difference in age,sex,admission etiology,SAPS score,and tracheotomy between the two groups(P0.05);but there were statistical difference in PaO2/FiO2,PIF,pulmonary compliance,and PEEP(P0.05). Conclusion The increase of pulmonary compliance and PaO2/FiO2,and increase of PEEP and PIF are the risk factors to the development of ARDS after mechanical ventilation.